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Use of a New Method for the Microbiological Diagnosis of Severe Corneal Infection

NCT05888987 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2024-09-19

No results posted yet for this study

Summary

Microbial keratitis is a severe and often blindness-inducing pathology which represents today the first reason for long-term hospitalization (more than 5 days) in ophthalmology. Its diagnosis is clinical and leads to an immediate hospitalization in the presence of serious criteria (Mackie classification). The entire process of microbiological diagnosis requires several days before etiological confirmation and therefore delays the initiation of targeted therapy.

Recently, new PCR systems allowing the detection of 18 to 27 pathogens in 75 minutes have been developed. Their use could thus be transposed to ophthalmology by adapting the microbiological diagnostic technique to samples currently taken by swabbing the cornea.

The investigators will compare their diagnosis performance versus conventional methods on patients who suffered for a microbial keratitis with severity criteria.

Conditions

  • Infectious Keratitis
  • Microbial Keratitis
  • Corneal Infection

Interventions

BIOLOGICAL

PCR multiplex by FilmArray

PCR multiplex by FilmArray system on corneal swabbing sample

Sponsors & Collaborators

  • CHU de Reims

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-07
Primary Completion
2027-01-07
Completion
2027-08-07

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05888987 on ClinicalTrials.gov