The Ocular Microbiome in Patients With Dry Eye Disease
NCT04656197 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80
Last updated 2020-12-07
Summary
The primary objective of this study is the characterization of the ocular microbiome in a healthy cohort and in patients with dry eye disease using whole-metagenome shotgun sequencing. Secondary objectives are the identification of differences between the ocular microbiome of healthy controls and patients with dry eye disease as well as between the ocular and the gut microbiome.
Conditions
Interventions
- OTHER
-
Ocular microbiome
Taxonomical and functional characterization of the ocular microbiome
Sponsors & Collaborators
-
Insel Gruppe AG, University Hospital Bern
lead OTHER
Principal Investigators
-
Martin Zinkernagel, Prof. Dr. Dr. · Department of Ophthalmology, Inselspital, Bern
Eligibility
- Min Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2019-09-30
- Primary Completion
- 2020-03-04
- Completion
- 2020-03-04
Countries
- Switzerland
Study Locations
More Related Trials
-
Non-invasive Diagnostics of Microbial Keratitis
NCT06364878 ·Status: RECRUITING
-
Ocular Surface Immune Response in Dry Eye Disease
NCT02042820 ·Status: COMPLETED
-
Study to Evaluate Corneal Neurosensory Abnormalities in Patients With Sjögren's Dry Eye
NCT06411132 ·Status: TERMINATED
-
Probiotic in Dry Eye Syndromes
NCT04938908 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of FID 114657 in Sjogren's Syndrome Subjects
NCT01079871 ·Status: COMPLETED ·Phase: NA
-
Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome
NCT05292755 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
NCT04296864 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Assess the Safety and Efficacy of IC265 Ophthalmic Solution for Dry Eye in Adult Participants
NCT05992922 ·Status: TERMINATED ·Phase: PHASE2
-
Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye
NCT00037661 ·Status: COMPLETED ·Phase: PHASE3
-
Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease
NCT05604651 ·Status: COMPLETED
-
Correlation of Different Signs for Assessment of Dry Eye Syndrome
NCT01753687 ·Status: COMPLETED ·Phase: NA
-
The Effects of a Single Intravenous Administration of Secukinumab (AIN457) or Canakinumab (ACZ885) in Dry Eye Patients
NCT01250171 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2b Study Evaluating the Safety and Efficacy of AR-15512 Ophthalmic Solution for the Treatment of Dry Eye Disease
NCT04498182 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients
NCT01468168 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease
NCT05865379 ·Status: RECRUITING ·Phase: NA
-
MSCohi-O Lenses for Ocular Involvement in Sjögren's Syndrome
NCT07185139 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye
NCT02965846 ·Status: TERMINATED ·Phase: PHASE3
-
A Study Evaluating the Efficacy and Safety of RCI001 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye
NCT07068958 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Evaluation of FID 114657 in Dry Eye Subjects
NCT01079858 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye
NCT03436576 ·Status: UNKNOWN ·Phase: PHASE3
-
The Evaluation of Thiol Redox Status in Conjunctiva of Dry Eye Patients
NCT00718926 ·Status: UNKNOWN
-
A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease
NCT05238597 ·Status: COMPLETED ·Phase: PHASE2
-
Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects
NCT05219461 ·Status: COMPLETED ·Phase: PHASE1
-
Preliminary Clinical Study of the Effectiveness and Safety of Ocular Surface Microbiota Transplantation in the Treatment of Dry Eye Disease
NCT07298811 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease
NCT02365519 ·Status: COMPLETED ·Phase: PHASE2