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Ocular Microbiome and Immune System in Dry Eyes

NCT04658238 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2025-04-01

No results posted yet for this study

Summary

The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease. Secondary objectives are the identification of differences in the ocular microbiome as well as in the immune system between participants with and without dry eye disease to ultimately find associations between the ocular microbiome and the immune system in dry eye disease.

Conditions

Interventions

OTHER

Ocular microbiome

Taxonomical and functional characterization of the ocular microbiome

OTHER

Ocular immune system

Functional characterization of the tear fluid proteome, histology of conjunctival tissue and molecular assays

Sponsors & Collaborators

  • Stiftung OPOS

    collaborator UNKNOWN

  • Fondation Bertarelli

    collaborator UNKNOWN

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Martin Zinkernagel, Prof. Dr. Dr. · Department of Ophthalmology, Inselspital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04658238 on ClinicalTrials.gov