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Carotid Plaque Imaging Project (CPIP)

NCT05821894 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 3500

Last updated 2024-10-15

No results posted yet for this study

Summary

The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.

Conditions

Interventions

OTHER

Observational study

Sponsors & Collaborators

  • Region Skåne

    collaborator UNKNOWN

  • The Swedish Research Council

    collaborator OTHER_GOV

  • Swedish Heart Lung Foundation

    collaborator OTHER

  • Skåne University Hospital funds (incl. the Medical Training and Research Agreement/ALF)

    collaborator UNKNOWN

  • Swedish Foundation for Strategic Research

    collaborator OTHER

  • Lund University

    lead OTHER

Principal Investigators

  • Isabel Goncalves, MD, PhD · Lund University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-10-26
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05821894 on ClinicalTrials.gov