Atherosclerosis is a chronic inflammatory arterial disease characterized by lipid-rich plaque buildup in vessel walls, leading to atherosclerotic cardiovascular disease. It underlies major events such as myocardial infarction, ischemic stroke, and peripheral arterial disease.
mRNA medicine and spatiotemporal drug delivery systems are expanding options for cardiovascular disease. The sources describe preclinical proof-of-concept, clinical trials and programmable cardiac repair platforms.
Diabetes and heart disease can impair sexual function by damaging blood vessels, nerves and circulation. Sexual dysfunction may also be an early warning sign of underlying vascular damage.
Merck will present late-breaking clinical data from its cardio-pulmonary pipeline at ACC.26, including positive Phase 3 results for enlicitide, an investigational oral PCSK9 inhibitor, and Phase 2 data for WINREVAIR in heart failure patients.
New research demonstrates RNA therapies can enhance heart regeneration after injury, while RNA biomarkers improve prediction of cardiovascular complications in chronic kidney disease patients.
The phase 3 OCEANIC-STROKE trial of 12,327 patients showed asundexian, an oral Factor XIa inhibitor, reduced ischemic stroke recurrence by 26% when added to standard antiplatelet therapy, with no increase in major bleeding events.
The cardiovascular biologics market is projected to reach $4.23 billion by 2033, while the cell therapy market is expected to reach $5.38 billion by 2032, driven by RNA-based therapies and regulatory approvals.
A phase three clinical trial shows enlicitide, an oral monoclonal antibody, reduced LDL cholesterol by 60% compared to placebo in 2,909 patients with or at risk of atherosclerosis over 24 weeks.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07558239 |
Carotid Intima-media Thickness in Dialysis Patients and Traditional Risk Factors |
NOT_YET_RECRUITING | |
| NCT07545408 |
Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus |
NOT_YET_RECRUITING | |
| NCT07524101 |
Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD |
NOT_YET_RECRUITING | NA |
| NCT07521007 |
A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis |
NOT_YET_RECRUITING | PHASE2 |
| NCT07448038 |
A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events |
RECRUITING | PHASE2 |
| NCT07266220 |
Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients. |
NOT_YET_RECRUITING | |
| NCT07220304 |
CaRi-Heart Assessment of Risk and Evaluation of Inflammation in Coronary CT Angiography (CARE-CCTA) |
NOT_YET_RECRUITING | NA |
| NCT07200804 |
Relationship Between Serum Vitamin D and Atherosclerosis in Hemodialysis Patients |
COMPLETED | |
| NCT07169682 |
Effects of IL17/23 Inhibitors on Markers of Subclinical Atherosclerosis in Patients With Psoriasis |
COMPLETED | |
| NCT07080151 |
Zhongshan Hospital Cardiovascular Imaging Registry |
NOT_YET_RECRUITING |
