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CT Evaluation of Carotid Plaque Components

NCT05764772 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2025-11-25

No results posted yet for this study

Summary

The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard.

The main question\[s\] it aims to answer are:

1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining.
2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden.

Participants will be asked to do the following:

Aim 1:

* 1 Photon counting/spectral CT angiography of the neck
* 1 Research Carotid/Neck MRI of the carotid arteries (if eligible)

Aim 2:

* 1 Research Carotid/Neck MRI of the carotid arteries (if eligible)
* 1 Photon counting/spectral CT angiography of the neck
* 1 Carotid plaque tissue from participants surgery will be retrieved, imaged, and stained (if eligible)

Conditions

  • Carotid Plaque

Sponsors & Collaborators

Principal Investigators

  • Jae W Song · University of Pennsylvania Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2026-08-31
Completion
2028-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05764772 on ClinicalTrials.gov