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Acute Dose-ranging Effects of Mango Leaf Extract (Zynamite® 15%) on Cognitive Function and Cerebral Blood Flow

NCT05580146 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2022-10-14

No results posted yet for this study

Summary

Zynamite® is a novel mango (Mangifera indica) leaf extract standardized to contain polyphenol mangiferin.It has previously been shown to enhance brain oxygenation, physical performance and ergogenic parameters following ischemia-reperfusion in healthy humans when consumed alongside other polyphenols. Preliminary data has also indicated that a single 300mg dose of Zynamite® (60%) can improve performance across a range of cognitive tasks.This study aims to evaluate the effects, in healthy adults, of 3 doses of Zynamite® 15% on performance across a number of cognitive domains, as well as during a period of cognitively demanding task performance. A second sub-study will assess cerebral blood flow during cognitively demanding task performance.

Conditions

  • Cognitive Change

Interventions

DIETARY_SUPPLEMENT

Zynamite® 15% 150mg

leaves of the mango food plant

DIETARY_SUPPLEMENT

Zynamite® 15% 300mg

leaves of the mango food plant

DIETARY_SUPPLEMENT

Zynamite® 15% 600mg

leaves of the mango food plant

DIETARY_SUPPLEMENT

Placebo

Sunflower oil matched for appearance

Sponsors & Collaborators

  • Nektium Pharma SL

    collaborator INDUSTRY

  • Northumbria University

    lead OTHER

Principal Investigators

  • David Kennedy, Prof · Northumbria University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-17
Primary Completion
2022-04-14
Completion
2022-04-14

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05580146 on ClinicalTrials.gov