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Effect of High-fat/High-sugar Diet on Food Reward Signaling

NCT05574660 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2022-10-10

No results posted yet for this study

Summary

In this randomized, single-blinded basic research study, healthy normal-weight human participants are exposed to a high-fat/high-sugar (HF/HS) snack or a low-fat/low-sugar (LF/LS) snack twice a day for eight weeks in addition to their regular diet. All participants are tested at baseline, after 4 weeks and after 8 weeks of dietary intervention.

At all time points the investigators acquire the following parameters:

* Body weight and composition,
* Blood parameters to control for metabolic changes,
* Visual analog scales (hunger, satiety, tiredness, etc.),
* Fat and sugar concentration preference,
* Functional Magnetic Resonance Imaging (fMRI) during a learning and a gustatory perception task.

The investigators hypothesize that the habitual consumption of a small HF/HS snack will reduce the preference for low-fat concentrations and will have an impact on brain response to the anticipation and consumption of palatable food. Moreover, the investigators hypothesize, that HF/HS diet will have an impact neuronal encoding of learning independent of food cues. The investigators expect these alterations independent of body weight gain suggesting a direct effect of HF/HS diet on neuronal circuits.

Conditions

  • Behavior, Eating

Interventions

DIETARY_SUPPLEMENT

High-Fat/High-Sugar (HF/HS) Diet

DIETARY_SUPPLEMENT

Low-Fat/Low-Sugar (LF/LS) Diet

Sponsors & Collaborators

  • Yale University

    collaborator OTHER

  • Max Planck Institute for Metabolism Research

    lead OTHER

Principal Investigators

  • Jens C Bruening, MD · Max Planck Institute for Metabolism Research

  • Dana M Small, PhD · Yale University

  • Marc Tittgemeyer, PhD · Max Planck Institute for Metabolism Research

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-09
Primary Completion
2018-10-24
Completion
2018-10-24

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05574660 on ClinicalTrials.gov