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Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males

NCT05551455 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2023-10-17

No results posted yet for this study

Summary

Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area. Participants will be asked to follow two 4-day (\~96 hours) periods of tightly controlled exercise energy expenditure (15 kcal/kg FFM/day \[cycling\]) and dietary intake (60 kcal/kg FFM/day) to compare a state of 'normal' energy availability (or energy balance; equivalent to 45 kcal/kg FFM/day) with concomitant 1: normal carbohydrate availability ('Normal'; \~60% of dietary intake from carbohydrate) and 2: low carbohydrate availability ('LCHF', \~1.5 g/kg carbohydrate per day, \~70 - 80% dietary intake from fat). This approximates the amount of carbohydrate consumed by an individual in a state of LEA through consuming 10 kcal/kg FFM/day with 50% of intake from carbohydrate, or \~1.5 g/kg/day of carbohydrate. In both experimental phases we will measure endocrine, metabolic and physiological parameters.

Conditions

  • Energy Supply; Deficiency
  • Carbohydrate Availability

Interventions

OTHER

Nutritional/dietary intake manipulation ('Normal')

Energy Intake provision (60 kcal/kg FFM/day) to elicit 'normal' energy availability (45 kcal/kg FFM/day), with 60% from carbohydrates.

OTHER

Nutritional/dietary intake manipulation ('Low')

Energy Intake provision (60 kcal/kg FFM/day), with 1.5 g/kg of carbohydrate and 70-80% fat intake, to elicit 'low' carbohydrate availability in energy balance (45 kcal/kg FFM/day).

Sponsors & Collaborators

  • Liverpool John Moores University

    lead OTHER

Principal Investigators

  • Jose L Areta · Liverpool John Moores University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-04
Primary Completion
2022-12-09
Completion
2022-12-09

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05551455 on ClinicalTrials.gov