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Effect of a Carbohydrate-rich Diet in Healthy Subjects

NCT04088344 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2019-09-12

No results posted yet for this study

Summary

The present research protocol will analyze whether a short-term modification (one week) of dietary habits would have an impact on the postprandial metabolism of dietary fatty acids and on their uptake by non-adipose tissues, in healthy subjects.

Each subject will participate in two protocols randomly determined and separated by a period of one month: a 7-day isocaloric diet (Protocol A) and a 7-day carbohydrate-rich diet containing +50% of the subject's energy needs. (Protocol B).

At the end of each diet, the subject will go through a postprandial metabolic study of 8 hours where different parameters will be measured thanks to PET imaging and perfusions of stables isotopes.

Conditions

  • Lipid Metabolism Disorder

Interventions

DIETARY_SUPPLEMENT

isocaloric diet

a 7-day isocaloric diet

DIETARY_SUPPLEMENT

Hypercaloric diet

A 7-day hypercaloric diet supplemented with carbohydrate-rich food (+ 50% of the subject's energy needs).

OTHER

Liquid meal

RADIATION

PET imaging

OTHER

perfusions of stable tracers

DEVICE

Indirect calorimetry

Sponsors & Collaborators

  • Hospices Civils de Lyon

    collaborator OTHER

  • Université de Sherbrooke

    lead OTHER

Principal Investigators

  • André Carpentier · Université de Sherbrooke

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-04-10
Primary Completion
2019-03-20
Completion
2019-07-02

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04088344 on ClinicalTrials.gov