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Inter-individual Variation in the Blood Pressure Lowering Effects of Dietary Nitrate

NCT05514821 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2023-12-05

No results posted yet for this study

Summary

Dietary nitrate supplementation, often in the form of beetroot juice, has been shown to lower blood pressure and could play a role in preventing or treating hypertension. However, it is currently unclear: a) how reproducible this response is within the same individual on different occasions, and b) whether there are genuine individual differences in the blood pressure lowering effects of dietary nitrate. This study will use a novel replicated cross-over design (2 x nitrate conditions, 2 x placebo conditions) to examine the reproducibility and inter-individual variability in the blood pressure lowering effects of dietary nitrate supplementation.

Conditions

  • Blood Pressure

Interventions

DIETARY_SUPPLEMENT

Beet It Sport Shot

Acute supplementation with 140 ml Beet It Sport Shots, James White Ltd, containing \~400mg dietary nitrate

DIETARY_SUPPLEMENT

Beet It Sport Shot Placebo

Acute supplementation with 140 ml Beet It Sport Shots Placebo, James White Ltd, in which the nitrate has been removed via an ion exchange resin, containing \~ 0 mg dietary nitrate

Sponsors & Collaborators

  • University of the West of Scotland

    collaborator OTHER

  • University of Nottingham

    collaborator OTHER

  • Aspire Academy

    collaborator OTHER_GOV

  • Liverpool John Moores University

    collaborator OTHER

  • Newcastle University

    lead OTHER

Principal Investigators

  • Oliver Shannon, PhD · Newcastle University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-10-15
Primary Completion
2023-09-25
Completion
2023-09-25

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05514821 on ClinicalTrials.gov