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Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease

NCT05401409 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-06-08

Study results available
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Summary

People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may contribute, in part, to high blood pressure in this condition. Nitrate is found in high concentrations naturally in beetroots, and increases NO. The aim of this study is to determine if beetroot juice reduces blood pressure in hypertensive people with ADPKD.

Conditions

  • Autosomal Dominant Polycystic Kidney
  • Hypertension
  • Endothelial Dysfunction

Interventions

DIETARY_SUPPLEMENT

Beetroot juice

70mls beetroot juice (400mg nitrate) given daily for 4 weeks

DIETARY_SUPPLEMENT

Nitrate-depleted beetroot juice

70mls beetroot juice (nitrate-depleted) given daily for 4 weeks

Sponsors & Collaborators

  • Westmead Institute for Medical Research

    collaborator UNKNOWN

  • Western Sydney Local Health District

    lead OTHER

Principal Investigators

  • G K Rangan · Westmead Hospital, Western Sydney Local Health District

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-05
Primary Completion
2023-03-24
Completion
2023-03-24

Countries

  • Australia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05401409 on ClinicalTrials.gov