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Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 186

Last updated 2018-11-16

No results posted yet for this study

Summary

This study aims to examine the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation patients using different ablation strategies such as : (i) pulmonary vein antrum isolation (PVAI) + isolation of left atrial posterior wall, (ii) PVAI plus scar homogenization, (iii) PVAI plus isolation of posterior wall plus ablation of non-PV triggers \[ PVAI: Pulmonary Vein Antrum Isolation

Non-PV triggers: Triggers arising from sites other than pulmonary veins\]

Conditions

  • Persistent Atrial Fibrillation
  • Long-standing Persistent Atrial Fibrillation

Interventions

PROCEDURE

Pulmonary Vein Antrum Isolation

Radio-frequency catheter ablation of pulmonary vein antrum extended to the left atrial posterior wall

PROCEDURE

scar homogenization

PVAI + RF energy will be delivered until all abnormal potentials in the low-voltage areas are eliminated.

PROCEDURE

Non-PV triggers ablation

PVAI + Isolation of LA posterior wall + Catheter ablation of triggers originating from extra-PV sites

Sponsors & Collaborators

  • RCCS Monzino Hospital, Milan, Italy

    collaborator UNKNOWN

  • Ospedale dell'Angelo, Venezia-Mestre

    collaborator OTHER

  • Texas Cardiac Arrhythmia Research Foundation

    lead OTHER

Principal Investigators

  • Andrea Natale, MD · TCAI

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2019-12-31
Completion
2020-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01672138 on ClinicalTrials.gov