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Brazil ICU Encephalitis Surveillance

NCT05370573 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 451

Last updated 2022-05-11

No results posted yet for this study

Summary

Our proposal is to develop a sentinel syndromic surveillance strategy to identify encephalitis cases possibly related to emerging pathogens admitted to ICUs in Brazil. "Sentinel" to allow a diagnostic intensive approach on a smaller number of cases, "syndromic" to guarantee a sensitive criterion to include new or unexpected pathogens, and in ICUs to prioritize potentially severe threats. In a resource-limited setting it won't be possible to monitor and investigate all cases of encephalitis, so a cost-effective algorithm for early identification of the cases that are most likely to be caused by unusual, unexpected or emerging pathogens must be developed. As universal surveillance of encephalitis is not recommended in Brazil, data on incidence, causes and prognosis is not available, leaving a gap in the understanding of the epidemiology of this central nervous system disease in the country. This study will review cases of encephalitis admitted in the last five years to ICUs in a large metropolitan area. Its results will help understand the epidemiology of encephalitis in Brazil and will provide data to build a strategy for early identification of outbreaks and of emerging infectious diseases.

Conditions

  • Encephalitis
  • Central Nervous System Infections and Inflammations
  • Intensive Care Neurological Disorder
  • Prognosis
  • Meningitis/Encephalitis
  • Meningitis

Interventions

OTHER

No intervention

Observational - no interventions

Sponsors & Collaborators

Principal Investigators

  • ANDRE M JAPIASSU, MD PDH · Instituto Nacional de Infectologia Evandro Chagas

Eligibility

Min Age
1 Month
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-01
Primary Completion
2020-06-01
Completion
2022-01-01

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05370573 on ClinicalTrials.gov