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Big Data and Genomic Imaging for the Development of Biomarkers and Nanovector Drugs Innovative for Diagnosis and Therapy of Inflammatory Processes in Dementia

NCT05761535 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 137

Last updated 2024-03-25

No results posted yet for this study

Summary

The correlation between data obtained by "imaging" in patients with neurodegenerative diseases characterized by inflammation and the presence in the peripheral blood of the same patients "biopsies liquid biopsies" of specific circulating nucleic acids, could enable the development of methods and algorithms capable of identifying novel biomarkers that serve as targets for the development of probes diagnostics and therapeutics. This is the context for the project idea, which is aimed at developing development of a performant multi parameter system capable of identifying novel biomarkers of microglial polarization that can be used for diagnostic and prognostic purposes in determining the staging/progression of neurodegenerative disease

Conditions

Interventions

RADIATION

Magnetic Resonance (MR) and positron emission tomograph (PET) imaging analyses

Regarding the neurological MR protocol, the following may be acquired: * 3D T1 and T2 high-resolution sequences, acquired in a specific plane and Multiplanar reformation (MPR) reconstructed in the remaining orthogonal planes, for morphological assessment of the different structures under examination; * diffusion sequences for the evaluation of the connection between different areas within a specific organ; * perfusion sequences (ASL, arterial spin labeling) for the evaluation of perfusion without ev mdc administration; * susceptibility sequences for noninvasive assessment of vasculature and deposits of iron.

Sponsors & Collaborators

  • IRCCS SYNLAB SDN

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-06-17
Primary Completion
2023-02-28
Completion
2023-06-30

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05761535 on ClinicalTrials.gov