Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors

Summary

The main goals of this study are to provide a cognitive, neurological, brain morphological, and serological profile of sepsis survivors in order to make long-term prognosis of recovery and estimate the need for rehabilitation measures in order to help patients reintegrate into normal daily life.

Conditions

• Severe Sepsis With Septic Shock
• Severe Sepsis Without Septic Shock

Interventions

PROCEDURE

Blood Sample

Blood Sample

BEHAVIORAL

Neurocognitive Assessment

Neurocognitive Assessment

OTHER

Resting State EEG

10-20 Minutes of Resting State EEG

PROCEDURE

Lumbar Puncture

Lumbar Puncture

OTHER

MRI

60 Minutes MRI

Sponsors & Collaborators

• University Hospital, Bonn

  collaborator OTHER

• German Center for Neurodegenerative Diseases (DZNE)

  lead OTHER

Principal Investigators

• Michael T Heneka, M.D. · German Center for Neurodegenerative Diseases (DZNE)

• Andreas Hoeft, M.D. · Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn

• Christian Putensen, M.D. · Research Unit Pulmonary Dysfunction and Sepsis, Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn

• Thomas Klockgether, M.D. · German Center for Neurodegenerative Diseases (DZNE)

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-09-30

Primary Completion

2017-10-31

Completion

2019-10-31

Countries

• Germany

Study Locations