MedTrace Logo

Randomized Trial of Sedative Choice for Intubation

NCT05277896 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 2367

Last updated 2026-03-25

Study results available
· View outcomes & findings →

Summary

Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains unknown. Ketamine and etomidate are the two most commonly used sedatives during intubation of critically ill adults. Data from a randomized clinical trial are urgently needed to determine the effect of ketamine versus etomidate on cardiovascular complications and clinical outcomes of emergency tracheal intubation.

Conditions

  • Acute Respiratory Failure

Interventions

DRUG

Ketamine

Intravenous ketamine as the sedative for induction of anesthesia during emergency tracheal intubation

DRUG

Etomidate

Intravenous etomidate as the sedative for induction of anesthesia during emergency tracheal intubation

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Patient-Centered Outcomes Research Institute

    collaborator OTHER

  • Vanderbilt University Medical Center

    lead OTHER

Principal Investigators

  • Jonathan D Casey, MD, MSc · Vanderbilt University Medical Center

  • Matthew W Semler, MD, MSc · Vanderbilt University Medical Center

  • Todd W Rice, MD, MSc · Vanderbilt University Medical Center

  • Wesley H Self, MD, MPH · Vanderbilt University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-06
Primary Completion
2025-09-06
Completion
2025-09-06
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05277896 on ClinicalTrials.gov