MedTrace Logo

Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients

NCT05092152 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 207

Last updated 2026-04-17

No results posted yet for this study

Summary

Rapid-sequence intubation is routinely performed in critically ill patients. It is unclear whether different sedative agents may influence short-term outcomes after intubation, specially hemodynamic stability.

Conditions

  • Acute Respiratory Failure

Interventions

DRUG

Esketamine

2 mg per kilogram of body weight

DRUG

Propofol

1.5 mg per kilogram of body weight

Sponsors & Collaborators

  • Federal University of São Paulo

    lead OTHER

Principal Investigators

  • Flavia R Machado, MD, PhD · Federal University of São Paulo

  • Raysa Schmidt, MD · Federal University of São Paulo

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-23
Primary Completion
2023-10-31
Completion
2023-12-31

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05092152 on ClinicalTrials.gov