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Effect of Degree of Polymerization and Linkage of α-glucans on Post-prandial Glucose Response

NCT05266690 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2022-03-04

No results posted yet for this study

Summary

The primary research project objective is to investigate whether a maltodextrin with high degree of polymerization (Roquette Glucidex 2) and a dextran with comparable degree of polymerization (Pharmacosmos Dextran 10) have lower post-prandial glucose response than glucose syrup (Roquette Glucidex 40). To confer further robustness to the results, the post-prandial glucose response will be compared to a negative control represented by a resistant dextrin with a complex structure containing 70% non-digestible dietary fiber (Promitor 70), which is currently used for sugar replacement.

Additional key objective is to investigate the safety and gastrointestinal tolerability of the investigational products.

Conditions

  • Postprandial Glucose Response

Interventions

DIETARY_SUPPLEMENT

Roquette Glucidex 2

Roquette Glucidex 2: Maltodextrins with high degree of polymerization

DIETARY_SUPPLEMENT

Pharmacosmos Dextran 10

Pharmacosmos Dextran 10: Dextran with high degree of polymerization

DIETARY_SUPPLEMENT

Roquette Glucidex 40

Roquette Glucidex 40: Glucose syrup

DIETARY_SUPPLEMENT

Promitor 70

Promitor 70: Resistant Dextrin with a complex structure containing 70% non-digestible dietary fiber

Sponsors & Collaborators

  • Société des Produits Nestlé (SPN)

    lead INDUSTRY

Principal Investigators

  • Pamela Sun, MD · Nestlé Research - Clinical Research Unit - Clinical Innovation Lab

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-29
Primary Completion
2020-02-18
Completion
2020-02-18

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05266690 on ClinicalTrials.gov