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Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty

NCT05204056 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2022-01-24

No results posted yet for this study

Summary

Sixty patients undergoing TKA were divided into three groups, then three different intro-operative articular cavity perfusion treatment was given according to the randomized, double-blind and controlled rule. One way ANOVA analysis on visual analogue scale (VAS) score, functional recovery, drainage, and edema of the affected limb were performed to assess the efficiency of the treatment in the following three days after the operation.

Conditions

  • Pain, Postoperative
  • Blood Loss, Postoperative

Interventions

DRUG

iced normal saline

Iced normal saline (20ml) was given intraoperative joint cavity infusion therapy

DRUG

Tranexamic acid injection

20ml of tranexamic was given with iced normal saline for intraoperative joint cavity infusion.

OTHER

Cocktail (composing by Ropivacaine, Morphine and Epinephrine) perfusion

Cocktail was formulated during the operation by mixing Ropivacaine 150mg, Morphine 10mg and Epinephrine 1mg, then normal saline was used to dilute the mixture to 60ml. Then the cocktail mixture was applied for the joint cavity perfusion.

Sponsors & Collaborators

  • Yantai Yuhuangding Hospital

    lead OTHER

Principal Investigators

  • Laijian Sui, Doctor · Yantai Yuhuangding Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-02
Primary Completion
2018-06-01
Completion
2018-08-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05204056 on ClinicalTrials.gov