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Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement

NCT01850394 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 152

Last updated 2013-12-13

Study results available
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Summary

The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee replacement, and 2) whether the blood loss reduction effect depended on the dose of tranexamic acid used.

Conditions

  • Primary Osteoarthritis of Knee Nos

Interventions

DRUG

Tranexamic Acid

Inject tranexamic acid solution intra-articularly after fascia closure

DRUG

Physiologic saline

Use physiologic saline for mixing with tranexamic acid or use alone in placebo group

Sponsors & Collaborators

  • Mahidol University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-01-31
Completion
2012-01-31

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01850394 on ClinicalTrials.gov