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The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

NCT07089251 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-07-28

No results posted yet for this study

Summary

The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.

Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration

Conditions

  • Knee Arthroplasty, Total
  • Knee Arthritis, Osteoarthritis
  • Total Knee Anthroplasty
  • Blood Loss
  • Tranexamic Acid Use
  • Epinephrine

Interventions

DRUG

low-dose epinephrine and tranexamic acid

low-dose epinephrine and tranexamic acid

DRUG

Tranexamic Acid (TXA) treatment

Tranexamic Acid

Sponsors & Collaborators

  • King Abdullah International Medical Research Center

    lead OTHER

Principal Investigators

  • Wazzan Aljuhani, MD, FRCSC, MBA, MMEd · King Abdulaziz Medical City, MNGHA

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-15
Primary Completion
2027-06-24
Completion
2027-06-24

Countries

  • Saudi Arabia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07089251 on ClinicalTrials.gov