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Conduction System Pacing vs Biventricular Resynchronization Therapy in Systolic Dysfunction and Wide QRS: CONSYST-CRT.

NCT05187611 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 130

Last updated 2025-07-10

No results posted yet for this study

Summary

Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS (CONSYST-CRT randomized clinical trial) is a non-inferiority trial that aims to study the composite endpoint consisting of all-cause mortality, cardiac transplant, heart failure hospitalizations, and left ventricular ejection fraction (LVEF) improvement \<5 points.

Conditions

  • Resynchronization Therapy
  • Conduction System Pacing

Interventions

DEVICE

Conduction system pacing

Lead placed in the His-Purkinje system in order to achieve QRS shortening.

DEVICE

Biventricular pacing

Lead is placed in a tributary of the coronary sinus.

Sponsors & Collaborators

  • Hospital Clinic of Barcelona

    lead OTHER

Principal Investigators

  • Lluís Mont, MD, PhD · Hospital Clinic of Barcelona

  • Jose M Tolosana, MD, PhD · Hospital Clinic of Barcelona

  • Margarida Pujol Lopez, MD · Hospital Clinic of Barcelona

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-17
Primary Completion
2024-07-15
Completion
2025-04-01
FDA Device
Yes

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05187611 on ClinicalTrials.gov