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REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

NCT05652218 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2026-05-06

No results posted yet for this study

Summary

Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide levels among patients with symptomatic HF, LVEF \> 35%, and LBBB.

Conditions

  • Left Ventricular Ejection Fraction
  • Heart Failure (HF)
  • Left Bundle-Branch Block

Interventions

DEVICE

LB-CRT

LB-CRT (DDD 60-130, LV lead turned off) (active intervention #1)

DEVICE

BIV-CRT

BIV-CRT (DDD 60- 130, LV lead turned on) (active intervention #2).

Sponsors & Collaborators

  • Medtronic

    collaborator INDUSTRY

  • Inova Health Care Services

    lead OTHER

Principal Investigators

  • Brett Atwater, MD · Inova Health Care Services

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-26
Primary Completion
2026-02-28
Completion
2026-09-30
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05652218 on ClinicalTrials.gov