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A Longitudinal Investigation of Energy Expenditure and Substrate Utilization in Critically Ill Patients

NCT05124860 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 714

Last updated 2025-04-11

No results posted yet for this study

Summary

The metabolic alterations associated with critical illness have significant implications for the nutritional management of ICU patients. Despite this, little is known about these changes in patients requiring prolonged organ support and nutritional therapy.

The overall aim of this study is to describe changes in metabolism over time in a large prospective cohort of patients requiring \>10 days of ICU care. Our hypothesis is that there is a significant change in mean energy expenditure and respiratory quotient (RQ) between the early (day 1-3), intermediate (day 4-10) and late (\>10 days) phase in ICU.

Conditions

  • Critical Illness

Interventions

DIAGNOSTIC_TEST

Indirect calorimetry

Measurement of metabolic rate (kcal/day) by respiratory gas analysis.

Sponsors & Collaborators

Principal Investigators

  • Martin Sundström Rehal, MD PhD · Karolinska University Hospital

  • Olav Rooyackers, PhD · Karolinska Institutet

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-21
Primary Completion
2024-07-18
Completion
2025-03-21

Countries

  • Australia
  • Netherlands
  • Sweden
  • Switzerland

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05124860 on ClinicalTrials.gov