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Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation

NCT01106300 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 63

Last updated 2015-12-18

No results posted yet for this study

Summary

Each year, 110,000 English/Welsh patients are admitted to Intensive Care Units (ICU). Many face prolonged disability as a result. Over two thirds have moderate-extreme limitation in their usual activity a year later, and one-third are severely affected, being unable to continue "most activities," or to live independently. Quite why known- but severe muscle wasting isn't may play an important role. We hope to find out, measuring the degree of wasting in patients, and seeking potential causes. We shall also address the mechanism of wasting, which may reflect an altered balance of activity in muscle growth pathways and those that break muscle down. We'll do this by collecting data, taking regular blood tests, scanning the leg muscles with an ultrasound machine, and analysing small muscle samples. In addition, we'll accurately and objectively measure how impaired these patients become, using specialist questionnaires, special monitoring equipment, simple walking tests and occasional special ('Cardio-Pulmonary') exercise tests. We'll try to see how badly activity is limited, and tease out whether muscle weakness plays a significant role in this. Finally, keeping muscles working (hard to do when unconscious/drowsy/bed-bound) may maintain muscle mass, so we'll see whether maintaining muscle activity using painless electrical stimulation will help.

Conditions

  • Critical Illness
  • Septic Shock
  • Trauma
  • Organ Failure

Sponsors & Collaborators

  • King's College London

    collaborator OTHER

  • Imperial College London

    collaborator OTHER

  • University of Nottingham

    collaborator OTHER

  • University College, London

    lead OTHER

Principal Investigators

  • Hugh Montgomery, MD · University College, London

  • Nicholas Hart, PhD · Guy's & St Thomas' NHS Foundation Trust, Kings College London

  • Zudin Puthucheary, MRCP · University College London, Whittington Hospital NHS Trust

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • United Kingdom

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01106300 on ClinicalTrials.gov