Algorithm to Stratify Clinical Decompensation Risk in Patients With Compensated Advanced Chronic Liver Disease (CHESS2108)

Summary

Compensated advanced chronic liver disease (cACLD) commonly indicates severe fibrosis and compensated cirrhosis at risk of developing clinically significant portal hypertension (CSPH) and hepatic decompensation. The presence of CSPH (defined as hepatic venous pressure gradient \[HVPG\] ≥ 10 mmHg) is the strongest predictor of hepatic decompensation. However, HVPG measurement is invasive, operator dependent, and not widely available. According to the 2021 updated EASL Clinical Practice Guidelines, cACLD patients who did not meet the Baveno VI criteria but had any of the two variables (LSM \> 20 kPa or PLT \< 150 × 109/L) were suggested to perform screening endoscopy and HVPG measurement. However, the number of cACLD patients with unfavorable Baveno VI status is huge, no detailed risk stratifications existed at this timepoint. This study intended to investigate a novel algorithm to stratify the decompensation risk in patients with cACLD.

Conditions

• Compensated Advanced Chronic Liver Disease

Interventions

DIAGNOSTIC_TEST

Esophagogasrtoduodendoscopy

Esophagogasrtoduodendoscopy was used to detech the presence of varices.

DIAGNOSTIC_TEST

Hepatic venous pressure gradient

A method used to eveluate the portal pressure

Sponsors & Collaborators

• Tianjin Second People's Hospital

  collaborator OTHER

• The Third People's Hospital of Taiyuan

  collaborator OTHER

• Ehime University Graduate School of Medicine

  collaborator OTHER

• Korea University Ansan Hospital

  collaborator OTHER

• Hyogo Medical University

  collaborator OTHER

• Zagazing University Faculty of Medicine

  collaborator UNKNOWN

• Institute of Liver and Biliary Sciences (ILBS)

  collaborator UNKNOWN

• Changi General Hospital

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Hepatopancreatobiliary Surgery Institute of Gansu Province

  lead OTHER

Principal Investigators

• Xiaolong Qi, MD · Lanzhou University First Affiliated Hospital

• Qing Xie, MD · Shanghai Jiao Tong university affiliated Ruijin Hospital

• Jia Li, MD · Tianjin Second People's Hospital

• Yu Jun Wong, MD · Changi General Hospital

• Masashi Hirooka, MD · Ehime University Graduate School of Medicine

• Hirayuki Enomoto, MD · Hyogo Medical University

• Tae Hyung Kim, MD · Korea UniversityAnsan Hospital

• Amr Shaaban Hanafy, MD · Zagazig University

• Ying Guo, MD · The Third People's Hospital of Taiyuan

• Shiv Sarin, MD · Institute of Liver and Biliary Sciences (ILBS)

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-01-01

Primary Completion

2023-01-01

Completion

2023-01-01

Countries

• China

Study Locations