SPIROMICS Study of Early COPD Progression (SOURCE)

Summary

This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals.

The study has three main goals:

* To use CT scan imaging to identify which smokers will develop COPD.
* To identify biomarkers predictive of smokers that will develop COPD.
* To determine if sputum (phlegm) can be analyzed to predict which smokers will develop COPD.

Procedures (methods): All participants will undergo study related questionnaires assessing medical history, smoke exposure and use, medication use, social and behavioral health, pulmonary symptoms, food frequency, and will provide nasal swab, blood, stool, and urine samples, pulmonary function testing to determine function, sputum induction to provide a sputum sample for airway biospecimen analysis, and CT imaging of the lungs.

Conditions

• COPD, Early-Onset

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• University of North Carolina, Chapel Hill

  collaborator OTHER

• Columbia University

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• National Jewish Health

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• University of Illinois at Chicago

  collaborator OTHER

• University of Iowa

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of Utah

  collaborator OTHER

• Wake Forest University Health Sciences

  collaborator OTHER

• Temple University

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• COPD Foundation

  collaborator OTHER

• Weill Medical College of Cornell University

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• University of Massachusetts, Worcester

  lead OTHER

Principal Investigators

• Fernando J Martinez, MD, MS · University of Massachusetts Chan Medical School

• MeiLan K Han, MD,MS · University of Michigan

• Jeffrey L Curtis, MD · University of Michigan

Eligibility

Min Age

30 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-09-08

Primary Completion

2026-04-30

Completion

2026-04-30

Countries

• United States

Study Locations