Determinants of Onset and Progression of COPD in Young Adults

Summary

COPD (Chronic Obstructive Pulmonary Disease) is a Public Health problem due to its impact in the patient's quality of life, high prevalence, growing incidence and socioeconomic implication. COPD natural history and first stages determinants are unknown. Knowing them will help to understand the natural history of the disease and to design interventions that can modify the prognosis of the disease.

Study objectives: (1) To characterize an early COPD population from a multidimensional point of view including demographic, social, family and clinical data, lung function, exercise capacity, image, microbiology, quality of life, exacerbations, comorbidities and blood and sputum biomarkers. (2) To compare this patients with smoking subjects, with normal lung function, matched by age, sex and site. (3) To create an early COPD cohort to be followed in the future to understand the complete natural history of the disease.

Methods: Design: multicenter cross-sectional study that will allow establishing a well-characterized cohort of early COPD patients for later follow-up. Recruitment will be done in Primary Care settings. Subjects: smokers (\> 10 packs year) between 35-50 years old with a spirometry (normal or obstructive) done in the last year. Diagnosis of COPD will be based on the smoking history and a postbronchodilator test FEV1(Forced Expiratory Volume in the first second) / FVC(Forced Vital Capacity) \< 70%. Age, sex and site matched 'healthy' smoker controls will be compared with the COPD cases. Variables that will be collected in the reference hospitals are: health questionnaires, lung function test, exercise capacity, blood and sputum samples, and low dose CT-scan. Statistical analysis: early COPD patient's characteristics will be described and then, will be compared, with control subjects through a conditional multiple logistic regression analysis.

Conditions

• COPD

Sponsors & Collaborators

• Spanish Research Center for Respiratory Diseases

  collaborator OTHER

• Hospital Son Espases

  collaborator OTHER

• Hospital Clinic of Barcelona

  collaborator OTHER

• Hospital del Mar

  collaborator OTHER

• Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

  collaborator OTHER

• Hospital Universitario 12 de Octubre

  collaborator OTHER

• Parc Taulí Hospital Universitari

  collaborator OTHER

• Hospitales Universitarios Virgen del Rocío

  collaborator OTHER

• Hospital Universitari de Bellvitge

  collaborator OTHER

• Hospital Arnau de Vilanova

  collaborator OTHER

• Hospital Universitario Central de Asturias

  collaborator OTHER

• University Hospital of the Nuestra Señora de Candelaria

  collaborator OTHER

• University Hospital A Coruña

  collaborator OTHER

• Barcelona Institute for Global Health

  collaborator OTHER

• Boehringer Ingelheim

  collaborator INDUSTRY

• Borja Cosio

  lead OTHER

Principal Investigators

• Borja Cosio, Medical Doctor · Spanish Research Center for Respiratory Diseases

Eligibility

Min Age

35 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2020-12-31

Completion

2020-12-31

Countries

• Spain