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The GUARDIAN Trial - Induction Agent Sub-Study

NCT04934683 · Status: ENROLLING_BY_INVITATION · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 6254

Last updated 2025-08-29

No results posted yet for this study

Summary

This is a sub-study of the overall GUARDIAN trial (NCT04884802) in which some GUARDIAN trial participants will be additionally randomized to etomidate vs propofol for anesthetic induction.

Conditions

  • Major Surgery

Interventions

PROCEDURE

Routine Blood Pressure Management

Routine blood pressure control.

PROCEDURE

Tight Blood Pressure Management

Tight blood pressure control.

DRUG

Etomidate Induction

Anesthetic induction with etomidate.

DRUG

Propofol Induction

Anesthetic induction with propofol.

Sponsors & Collaborators

  • The University of Texas Health Science Center, Houston

    lead OTHER

Principal Investigators

  • Daniel I Sessler, MD · The University of Texas Health Science Center, Houston

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-25
Primary Completion
2026-12-31
Completion
2027-04-25
FDA Drug
Yes

Countries

  • United States
  • China
  • Greece
  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04934683 on ClinicalTrials.gov