MedTrace Logo

Imunomodulation in Acute Pancreatitis

NCT04796311 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2024-02-28

No results posted yet for this study

Summary

Acute pancreatitis is an acute inflammatory pathology of the pancreas with activation of both innate and adaptive immune system, including T and B lymphocytes and release of inflammatory cytokines. We aim to characterize the circulating profile of T and B cells, its regulatory populations and B cell maturation, as well as inflammatory cytokines, in a prospective way of 50 patients with acute pancreatitis admitted to Hospital da Luz Lisboa. Blood samples will be collected at hospital admission, 48h, one month and 6 months after hospitalization of patients, relating these values to the severity of acute pancreatitis. Patients with acute pancreatitis in the previous 6 months, diabetes mellitus, pregnant women, uncontrolled comorbidity and terminal neoplasms will be excluded. A control group of 30 ambulatory individuals observed at the Hospital da Luz Lisboa will be recruited. Laboratory evaluation will be performed at the Immunology Laboratory of NOVA Medical School.

Conditions

Interventions

DIAGNOSTIC_TEST

blood samples

T cells, B cells and cytokines testing

Sponsors & Collaborators

  • Filipa Malheiro

    lead OTHER

Principal Investigators

  • Filipa Malheiro, MD · Hospital da Luz, Lisboa

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-26
Primary Completion
2023-09-30
Completion
2023-12-30

Countries

  • Portugal

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04796311 on ClinicalTrials.gov