MedTrace Logo

Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

NCT05670301 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2500

Last updated 2024-09-19

No results posted yet for this study

Summary

A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation

The goal of this prospective, observational study is to describe the longitudinal evolution of blood cytokine profiles in patients with presumed or confirmed diseases of systemic inflammation

The main questions it aims to answer are:

* What are the differences and similarities in blood cytokines between different patients and groups presenting symptoms of systemic inflammatory conditions?
* How is the cytokine profile of individual patients evolving over time and what is the effect of different therapeutics?
* Is cytokine profiling a valuable tool to diagnose and follow-up on patients with systemic inflammatory conditions?

Participants will be asked to give an additional blood volume for research purposes when blood sampling is performed for routine clinical purposes. A subset of patients (those initiated on biologicals) will also be asked to complete questionnaires.

Researchers will compare the blood cytokines profiles between the different groups of systemic inflammatory conditions and with healthy individuals.

Conditions

Interventions

DIAGNOSTIC_TEST

cytokine and lipidomic profiling

* FEBRIS Cytokine Profile Assay (quantification of inflammatory cytokines) * Serum amyloid A * Biobanking of leftover sample for future analyses and specific immunofunctional assay in selected cases * Lipidomics

Sponsors & Collaborators

  • University Hospital, Antwerp

    collaborator OTHER

  • Ziekenhuis Netwerk Antwerpen (ZNA)

    collaborator OTHER

  • Universitair Ziekenhuis Brussel

    collaborator OTHER

  • Jessa Hospital

    collaborator OTHER

  • Hasselt University

    collaborator OTHER

  • University Hospital, Ghent

    lead OTHER

Principal Investigators

  • Filomeen Haerynck · University Ghent

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-28
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05670301 on ClinicalTrials.gov