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Role of ST2 in Acute Pancreatitis

NCT01315613 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 44

Last updated 2011-03-15

No results posted yet for this study

Summary

Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.

Conditions

Sponsors & Collaborators

  • Erasme University Hospital

    lead OTHER

Principal Investigators

  • Romy Ouziel, MD · Erasme hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2008-09-30
Completion
2008-09-30

Countries

  • Belgium

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01315613 on ClinicalTrials.gov