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iMmune SignAtures and Clinical outComes in AP

NCT05878236 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 198

Last updated 2025-08-22

No results posted yet for this study

Summary

The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants will provide blood samples and complete patient surveys and interviews within 36 hours of hospital presentation, at 48 hours, and hospital day 7 (if admitted). Data on hospital stay, medical history, clinical course, and severity of disease will be collected.

Conditions

Interventions

DIAGNOSTIC_TEST

CyTOF Analysis

CyTOF laboratory testing for cytokine levels to correlate with severity of acute pancreatitis

Sponsors & Collaborators

  • University of Pittsburgh

    collaborator OTHER

  • University of Illinois at Chicago

    collaborator OTHER

  • University of Southern California

    collaborator OTHER

  • Benaroya Research Institute

    collaborator OTHER

  • Ohio State University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-06
Primary Completion
2026-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05878236 on ClinicalTrials.gov