Sarcopenia and Nutritional Status in a Rehabilitation Setting

Summary

In this pilot observational study the primary outcome is to assess, in a Respiratory Rehabilitation Unit, if there is an association between sarcopenia, assessed by handgrip strenght and BIA, and a delayed decannulation time in patients who underwent tracheostomy.

Secondary outcomes are to assess if there is an association between an increased malnutrition risk (assessed by MUST), a poor nutritional status (assessed by GLIM criteria) and a delayed decannulation time and the gut microbiota composition.

Conditions

• Sarcopenia

Interventions

DIAGNOSTIC_TEST

handgrip strenght

Muscle strenght measured with a handheld dynamometer, at admission (T0) and at decannulation time (T1)

DIAGNOSTIC_TEST

Bioelectrical Impedance Analysis (BIA)

Muscle mass evaluated by Bioelectrical Impedance Analysis (BIA), at admission (T0) and at decannulation time (T1)

DIAGNOSTIC_TEST

MUST

Malnutrition risk assessed by Malnutrition Universal Screening Tool (MUST), at admission (T0) and at decannulation time (T1)

DIAGNOSTIC_TEST

GLIM

Malnutrition diagnosis performed by Global Leadership Initiative on Malnutrition (GLIM) criteria, at admission (T0) and at decannulation time (T1)

BIOLOGICAL

Gut microbiota

A fecal sample obtained at admission (T0) and at decannulation time (T1)

BIOLOGICAL

Blood Sample

A Blood sample obtained at admission (T0) and at decannulation time (T1)

OTHER

Anthropometric measures

Measurement of weight and height (assessed only at admission) to calculate the Body Mass Index (BMI), at admission (T0) and at decannulation time (T1)

Sponsors & Collaborators

• University of Florence

  collaborator OTHER

• Fondazione Don Carlo Gnocchi Onlus

  lead OTHER

Principal Investigators

• Chiara F Gheri, MD · Fondazione Don Carlo Gnocchi Onlus

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-06-09

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• Italy

Study Locations