Community Acquired Pneumonia in Older Adults

Summary

This study will utilize diagnostic imaging and salivary biomarkers to estimate the prevalence of aspiration in older adults with suspected community-acquired bacterial pneumonia (CABP). 150 participants over the age of 60 diagnosed with pneumonia will be recruited into this study. 62 of these participants will be enrolled in a supplemental study.

Conditions

• Pneumonia
• Aspiration Pneumonia

Interventions

DIAGNOSTIC_TEST

Videofluoroscopic Swallowing Study

Participants enrolled in supplemental study will swallow different barium containing liquid and food boluses types that are captured on fluoroscopic imaging in real time.

DIAGNOSTIC_TEST

Nuclear medicine pulmonary aspiration study

Participants enrolled in supplemental study will be administered radiotracer (Tc-99m-Sulfur Colloid) orally and static images of the chest will then be obtained at specified intervals over the next 2 hours to determine location of the radiotracer.

DIAGNOSTIC_TEST

TOR-BSST and 3 oz Water Swallow

The research specialist will conduct ten 1 tsp water swallows, one cup sip of water and a 3 ounce water swallow test with the patient. After each swallow, the participant is asked to say "ah" so that their voice quality can be assessed.

DIAGNOSTIC_TEST

Sputum Culture

Patients will have sputum collected during stay (ED participants only)

DIAGNOSTIC_TEST

MeMed BV®

A blood test to help determine if the infection is viral or bacterial (ED participants only)

DIAGNOSTIC_TEST

Lung Ultrasound

To image the lungs (ED participants only)

DIAGNOSTIC_TEST

Respiratory Function Tests

To measure respiratory pressures.

Sponsors & Collaborators

• Gordon and Betty Moore Foundation

  collaborator OTHER

• University of Wisconsin, Madison

  lead OTHER

Principal Investigators

• Michael Pulia, MD, MS · University of Wisconsin, Madison

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-02-24

Primary Completion

2023-07-02

Completion

2023-07-02

FDA Drug

Yes

Countries

• United States

Study Locations