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Lung Function Decline and Disease Risk From Young Adulthood to Middle Age

NCT02245178 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3193

Last updated 2018-08-22

No results posted yet for this study

Summary

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified. Individuals with lung disease frequently have concurrent cardiovascular disease, but the reason for this is not well understood. In this study, we will identify markers that predict risk of future lung disease and evaluate the concurrent subclinical evolution of lung and heart dysfunction. This will allow for targeting of preventive strategies to stop the rising incidence of COPD and other lung diseases and provide insights into why heart and lung disease frequently occur together.

Conditions

  • COPD
  • Lung Function
  • Heart - Lung Interaction
  • Restrictive Lung Disease

Interventions

PROCEDURE

Lung spirometry

measurement of pulmonary function pre- and post-bronchodilator

OTHER

CT scan analysis

Analysis of existing year 25 thoracic CT scans for lung and intrathoracic vascular structure

Sponsors & Collaborators

  • University of Minnesota

    collaborator OTHER

  • University of Alabama at Birmingham

    collaborator OTHER

  • University of Kentucky

    collaborator OTHER

  • Kaiser Foundation Research Institute

    collaborator OTHER

  • Brigham and Women's Hospital

    collaborator OTHER

  • Vanderbilt University

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Northwestern University

    lead OTHER

Principal Investigators

  • Ravi Kalhan, MD · Northwestern University

Eligibility

Min Age
48 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2016-08-31
Completion
2018-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02245178 on ClinicalTrials.gov