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Collection of Lung Fluid and Tissue Samples for Research

NCT00471250 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 550

Last updated 2026-05-07

No results posted yet for this study

Summary

This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections. The specimens will be examined for differences between the two groups that may be associated with susceptibility to certain infections.

Healthy normal volunteers and people with a history of lung infections between 18 and 75 years of age who are followed at NIH may be eligible for this study.

Participants undergo the following procedures:

Medical history and physical examination.

Blood and urine tests.

Electrocardiogram (ECG) and chest x-ray.

Treadmill exercise stress test (for people over 45 years old with a history of chest pain or ECG abnormalities).

Bronchoscopy: The subject s nose and throat are numbed with lidocaine and a sedative is given for comfort. A thin flexible tube called a bronchoscope is advanced through the nose or mouth into the lung airways to examine the airways carefully.

Fluid collection during the bronchoscopy using one of the following methods:

* Bronchoalveolar lavage: Salt water is injected through the bronchoscope into the lung and immediately suctioned out, washing off cells lining the airways.
* Bronchial brushings: A brush-tipped wire enclosed in a sheath is passed through the bronchoscope and a small area of the airway tissue is gently brushed. The brush is withdrawn with some tissue adhering to it.
* Endobronchial biopsies: Small pinchers on a wire are passed through the bronchoscope and about 1 to 2 millimeters of tissue is removed.
* Nasal scrape: A small device is used to scrape along the inside of the nose to collect some cells.
* Sputum induction
* Exhaled breath condensate to obtain specimens for in vitro investigations and comparisons of both the cellular and acellular components.
* Nasal nitric oxide production
* Nasal potential difference
* Exhaled aerosol mask sample collection
* Cough aerosol collection
* Exhaled particle collection
* Lung Clearance Index (LCI)

Conditions

  • Leukocyte Disorders
  • Respiratory Tract Diseases
  • Bronchoscopy

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Andrew J Lipton, M.D. · National Heart, Lung, and Blood Institute (NHLBI)

Eligibility

Min Age
5 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-08-17

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00471250 on ClinicalTrials.gov