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Biomarkers Of Lung InVolvement In ASMD

NCT05914727 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2023-06-22

No results posted yet for this study

Summary

The goal of this study is to characterize ASMD patients' breath profile, exhaled breath and condensate as compared to healthy controls to identify specific volatile and non-volatile compounds that reflect inflammatory processes, fibrotic processes or sphingolipid accumulation in the lungs.

Participants will be provided exhaled breath samples in three ways (breath profile, volatile compounds and condensate). ASMD patients will be compared to age- and sex-matched healthy controls.

Conditions

  • Asmd, Visceral Type

Interventions

DIAGNOSTIC_TEST

eNose

Collection of breath profile with eNose

DIAGNOSTIC_TEST

Volatile exhaled breath sample

Collection of exhaled breath in Tedlar bag

DIAGNOSTIC_TEST

Condensate sample

Collection of exhaled breath condensate with EcoScreen

Sponsors & Collaborators

  • Eline C. B. Eskes

    lead OTHER

Principal Investigators

  • Carla EM Hollak, MD, PhD, prof · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-05
Primary Completion
2024-04-01
Completion
2024-09-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05914727 on ClinicalTrials.gov