Digitally-enhanced, Decentralized, Multi-omics Observational Cohort

Summary

The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and remote assessment of the symptoms of preclinical stages in Alzheimer's disease and movement disorders, e.g. Parkinson's. For this study we are looking for participants aged over 45 without cognitive complaints or with subjective perception of cognitive decline or with mild cognitive complaints. Specific aims for the proposed study: a) to develop novel sensitive measures that can provide an early identification of those SCD and MCI individuals harboring AD pathology that are at high risk of cognitive worsening over time; b) to track pre-motor stages in Parkinson's disease and trials that enable active digital functional biomarkers; c) to track disease progression during pre-dementia and pre-motor stages in clinical practice and trials with measures that enable to capture subtle changes.

Conditions

• Presymptomatic Disease
• Mild Cognitive Impairment
• Memory Loss (Excluding Dementia)
• Cognitive Change
• Dementia
• Alzheimer Disease
• Parkinson's Disease and Parkinsonism

Interventions

DIAGNOSTIC_TEST

Teleph0s digital phenotyping platform

Computerized multimodal assessment of complex neurological and psychiatric interviews (AI-COPE).

Sponsors & Collaborators

• Ionian University

  collaborator OTHER

• Greek Alzheimer's Association and Related Disorders

  collaborator OTHER

• Panhellenic Federation of Alzheimer's Disease and Related Disorders

  collaborator OTHER

• Barcelona Clinic Hospital (HCB), Spain

  collaborator UNKNOWN

• Teleph0s LLC

  collaborator UNKNOWN

• Greece 2021 Committee

  lead OTHER_GOV

Principal Investigators

• Panagiotis Vlamos, PhD · Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University

Eligibility

Min Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-03-15

Primary Completion

2031-10-30

Completion

2031-11-30

FDA Device

Yes

Countries

• Greece
• Spain

Study Locations