Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects

Summary

The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.

Conditions

• Motoric Cognitive Risk Syndrome
• Mild Cognitive Impairment
• Alzheimer Disease
• Dementia

Interventions

PROCEDURE

MRI evaluation

Multimodal MRI evaluation : * T1 structural, * Resting echo planar imaging * Diffusion-weighted imaging * Arterial sping labeling * Fluid-attenuated inversion recovery

BEHAVIORAL

Actimetry & IMU

Evaluation of daily activities and life rythms (physical activity, inactivity, sleep) using actimeters (Motion 8), inertial sensors (GaitUP) and questionaires during 14 days : * Actimetry : evaluation of daily activity and inactivity, sleep rythms * Inertial sensors : gait evaluation during daily activities * Questionaires : sleep (Spiegel \& St Mary's Hospitral) and fatigue (MFI-20)

BEHAVIORAL

Gait evaluation

Evaluation of gait characteristics (spatio-temporal parameters \& non-linear characteristics) in virtual environment : * Locomotor simple task : gait only in congruent environment * Locomotor dual task : gait in similar environment combined with a visually displayed Stroop task * Sensorimotor gait adaptaition : evaluation of the adaptation capability throughout a split-belt treadmill sequence (realized in simple or dual -combined with the visual Stroop task-)

BEHAVIORAL

Neuropsychological evaluation

Complete neuropsychological examination including attentional and executive functions, learning and retrieval abilities in episodic memory and general cognitive skills : * Divided attention (TAP; test of attentional performance) * California Verbal Learning Test * The Rey-Osterrieth Complex Figure * Symbol search and coding (WAIS-IV) * Go/No-go (TAP) * Flexibility (TAP) * Original task of multimodal integration * Verbal fluencies (GREFEX)

Sponsors & Collaborators

• University Hospital, Caen

  lead OTHER

Principal Investigators

• Pierre Denise, MD, PhD · CHU de Caen Normandie

Eligibility

Min Age

55 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-01-26

Primary Completion

2023-12-30

Completion

2024-12-30

Countries

• France

Study Locations