Cognitive Function Evaluation and Rehabilitation by a Digital Game: MentalPlus®

Summary

Cognitive dysfunction is a frequent adverse event in the postoperative period, especially in elderly patients. The tests commonly used for the detection of postoperative cognitive dysfunction (POCD) are time-consuming, which limits routine use. Consequently, there is a limitation to adopting measures to increase preoperative cognitive reserve and rehabilitation of POCD. That situation incentivizes searching for alternative diagnosis methods to overcome that limitation. Digital games have potential neuromodulator effects and have been used as an alternative to psychotherapeutic treatment. However, the tests used to detect postoperative cognitive dysfunction (POCD) are time-consuming, making it difficult to implement routine screening measures. This presents a challenge for increasing preoperative cognitive reserve and rehabilitating POCD. Researchers are exploring alternative diagnostic methods, such as digital games, to address this challenge. Digital games have potential neuromodulator effects and are an alternative to psychotherapeutic treatments and cognitive rehabilitation. This study aims to validate MentalPlus®, a digital game, as a tool for cognitive assessment, POCD evaluation, and POCD rehabilitation-habilitation of mental skills. It is hypothesized that a digital game could replace the usual neuropsychological tests for detecting POCD.

Conditions

• Neuropsychological Test

Interventions

DEVICE

MentalPlus®

A digital game named MentalPlus will be used to evaluate the possibility of this game becoming a neuropsychological test.

Sponsors & Collaborators

• University of Copenhagen

  collaborator OTHER

• Max Planck Institute for Human Development

  collaborator OTHER

• Karolinska Institutet

  collaborator OTHER

• The Cleveland Clinic

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• UMC Utrecht

  collaborator OTHER

• Harvard Medical School (HMS and HSDM)

  collaborator OTHER

• Keio University

  collaborator OTHER

• California Institute of Technology

  collaborator OTHER

• University of Sao Paulo

  lead OTHER

Principal Investigators

• Livia S Valentin, Ph.D · University of Sao Paulo School of Medicine

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-07-08

Primary Completion

2022-11-29

Completion

2023-11-29

Countries

• Brazil

Study Locations