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Millet-based Muffins, Glycaemic Response, Insulinemic Response and Gastric Emptying

NCT04599738 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2020-10-23

No results posted yet for this study

Summary

Millet is a functional grain that has attracted the attention of scientists for many years due to its significant benefits to human health. Research has shown that millets have a high antioxidant capacity and polyphenol content which can contribute to a reduced risk of some chronic diseases such as type 2 diabetes and its complications. This study aimed to assess the glycaemic response (GR), insulinaemic response (IR) and gastric emptying (GE) after the consumption of millet-based muffins in pre-diabetic and healthy participants.

This was a single-blind, randomized controlled crossover study in which participants consumed one control muffin (wheat) and one test muffin (millet). During each session, participants were required to consume either the test or the control muffin, consuming the alternative on the next visit. Then, 10 finger-prick blood samples were taken for the determination of glucose and insulin over 4 hours. 13Carbon (13C) sodium acetate was added to the muffins (control and test) in order to measure gastric emptying from the breath samples collected.

Conditions

  • Healthy
  • Pre Diabetes

Interventions

OTHER

Wheat muffin

Participants consumed a control muffin made of wheat flour.

OTHER

Finger millet grain muffin

Participants consumed a test muffin made of finger millet grain and wheat flour.

Sponsors & Collaborators

  • Taibah University

    collaborator OTHER

  • Oxford Brookes University

    lead OTHER

Principal Investigators

  • Sangeetha Thondre · Oxford Brookes University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-06
Primary Completion
2017-12-24
Completion
2017-12-24

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04599738 on ClinicalTrials.gov