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Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

NCT04502225 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2025-11-06

No results posted yet for this study

Summary

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

Conditions

  • Supine Hypertension
  • Autonomic Failure

Interventions

OTHER

Tilt

Tilt of the whole bed so that the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHER

Elevated trunk

Elevation of the trunk through raising just the head of the bed until the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHER

Tilt - In home

Tilt of the whole bed so that the head is elevated by 8 inches overnight.

OTHER

Elevated Trunk - In home

Elevation of the trunk through raising the head 8 inches on a wedge pillow overnight.

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    lead OTHER

Principal Investigators

  • Italo Biaggioni, MD · Vanderbilt University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-21
Primary Completion
2026-08-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04502225 on ClinicalTrials.gov