MedTrace Logo

Vasopressin in Intraabdominal Pressure Elevation

NCT03707054 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2026-04-29

Study results available
· View outcomes & findings →

Summary

The aim of this study is to investigate any direct correlation between increased intrathoracic pressure, intraabdominal pressure and intracranial pressure, following a controlled elevation in intraabdominal pressure and intrathoracic pressure (PEEP). The second end-point is to investigate any correlation between elevated intracranial pressure and vasopressin release, urine output and urine and serum osmolality by measuring their values at different time-points.

Conditions

  • Intracranial Pressure Increase
  • Abdominal Compartment Syndrome

Interventions

DIAGNOSTIC_TEST

Study Arm

Measurements of optic nerve diameter, serum and urine osmolarity, serum vasopressin

Sponsors & Collaborators

  • The Cleveland Clinic

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
72 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-04-28
Primary Completion
2024-05-28
Completion
2024-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03707054 on ClinicalTrials.gov