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Safety and Efficacy of L-NAME and Midodrine to Increase MAP

NCT00835224 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2014-04-23

Study results available
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Summary

After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day in persons with spinal cord injury.

Conditions

  • Orthostatic Hypotension
  • Spinal Cord Injury

Interventions

DRUG

L-NAME

A non-selective inhibitor of nitric oxide synthase and placebo. It has been used experimentally to induce hypertension.

DRUG

Midodrine

To treat low blood pressure.

DRUG

Placebo

A pill with an inactive substance that looks like the study drug.

Sponsors & Collaborators

Principal Investigators

  • Jill Wecht, EdD · VA Medical Center, Bronx

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2013-06-30
Completion
2013-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00835224 on ClinicalTrials.gov