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Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

NCT04242602 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2026-03-30

No results posted yet for this study

Summary

Various methods have been studied to evaluate autoregulation. However, there is currently no universally accepted technique to assess integrity of the cerebral autoregulation neurovascular system. In the last decade, significant progress has been achieved in developing methods to assess cerebral autoregulation by quantifying cross-correlation between spontaneous oscillations in CBF or oxygenation and similar oscillations in arterial blood pressure.

In this study the investigators will analyze the relationship between spontaneous fluctuations in mean arterial blood pressure and cerebral blood flow velocity or cerebral regional oxygenation to investigate two novel methods for measuring cerebral autoregulation, Transfer Function Analysis and Wavelet Coherence after acute pediatric brain injury.

Conditions

Interventions

DEVICE

Transcranial Doppler

Record flow velocity tracing of middle cerebral artery using a transcranial doppler.

Sponsors & Collaborators

  • The University of Texas at Arlington

    collaborator OTHER

  • Southern Methodist University

    collaborator OTHER

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Darryl Miles · University of Texas Southwestern Medical Center

Eligibility

Min Age
28 Days
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-06
Primary Completion
2020-09-10
Completion
2020-09-10

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04242602 on ClinicalTrials.gov