Neuronal Mechanisms of Human Episodic Memory

Summary

The purpose the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, and making decisions or choices about presented information. These investigations are critical to better understand human cognition and to design treatments for disorders of learning and memory.

Conditions

• Epilepsy Intractable

Interventions

BEHAVIORAL

Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator

Devices listed are components of a single intervention that includes: Record patient responses (Cedrus RB-844), record neuronal activity (Neurolynx) from electrodes (Adtech Behnke-Fried), apply intermittent electrical stimulation (Blackrock Cerestim)

Sponsors & Collaborators

• Johns Hopkins University

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• Boston Children's Hospital

  collaborator OTHER

• University of California, Santa Barbara

  collaborator OTHER

• National Institute of Neurological Disorders and Stroke (NINDS)

  collaborator NIH

• California Institute of Technology

  collaborator OTHER

• Cedars-Sinai Medical Center

  lead OTHER

Principal Investigators

• Ueli Rutishauser, PhD · Cedars-Sinai Medical Center

• Adam Mamelak, MD · Cedars-Sinai Medical Center

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

13 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-12

Primary Completion

2026-07-31

Completion

2026-07-31

Countries

• United States

Study Locations