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Localizing Epileptic Networks Using MRI and iEEG

NCT04649008 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 290

Last updated 2026-02-13

No results posted yet for this study

Summary

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Conditions

  • Epilepsy
  • Epilepsy Intractable
  • Epilepsy, Temporal Lobe

Interventions

DIAGNOSTIC_TEST

3T Magnetic Resonance Imaging

Magnetic resonance imaging acquired at a field strength of 3 Tesla.

DIAGNOSTIC_TEST

Intracranial electroencephalography recordings

Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.

DIAGNOSTIC_TEST

7T Magnetic Resonance Imaging

Magnetic resonance imaging acquired at a field strength of 7 Tesla.

Sponsors & Collaborators

Principal Investigators

  • Kathryn A Davis, MD, MSTR · University of Pennsylvania

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2027-02-28
Completion
2027-02-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04649008 on ClinicalTrials.gov