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Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

NCT04439370 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 160

Last updated 2026-01-08

No results posted yet for this study

Summary

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Conditions

Interventions

DIAGNOSTIC_TEST

Blood tests

Serum FSH, estrogen, progesterone, and testosterone will be measured

DIAGNOSTIC_TEST

Microneurography to measure muscle sympathetic nerve activity (MSNA)

Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves

DIAGNOSTIC_TEST

Baroreflex sensitivity testing

Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.

DIAGNOSTIC_TEST

Sympathoexcitatory Maneuvers

Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed

Sponsors & Collaborators

Eligibility

Min Age
35 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-10-01
Primary Completion
2026-12-30
Completion
2026-12-30

Countries

  • United States

Study Locations

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Entities

Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04439370 on ClinicalTrials.gov